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| c. 15,000 years ago |
| | | The La Brea tarpit in Los Angeles shows signs of human activity in the region | |
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| c. 15,000 years ago |
| | | Archaeological evidence reveals that the central plains of north America by now have a widespread human population | |
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| 8000 BC |
| | | As the ice cap recedes, hunter-gatherers move up the eastern side of America into Newfoundland and the prairie provinces of Canada | |
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| c. 8000 BC |
| | | As temperatures warm, the sea level rises, submerging the Bering land bridge and isolating the Siberian immigrants as the aboriginal Americans | |
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| c. 1000 BC |
| | | Burial mounds feature in the Ohio valley, built first in the Adena culture and then by Hopewell tribes | |
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| 1540 |
| | | Francisco Vasquez de Coronado penetrates far north and west of Texas in an expedition searching for gold | |
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| 1585 |
| | | Roanoke Island, off the coast of North Carolina, is settled by the first English colonists in America – with disastrous results | |
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| c. 1585 |
| | | The English artist John White paints the everyday life of the Secotan Indians of America | |
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| 1587 |
| | | A new group of English settlers arrives at Roanoke Island and makes a second attempt at a settlement | |
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| 1587 |
| | | Virginia Dare becomes the first English child to be born in America, on Roanoke Island | |
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